Viagra Found Helpful for Heart Problems

Viagra could help treat diastolic heart failure Recent research into Viagra has found that it can also be used effectively to reduce and treat the effects of heart disease. The study showed that the little blue tablet which has already been so widely successful in treating erectile dysfunction has also got the potential to revolutionize the way doctors treat heart patients.

The latest study was carried out in Germany and the U.S. and was able to show that it is the relaxing effect of Sildenafil (Viagra’s active ingredient) which is of benefit to sufferers of diastolic heart failure. Researchers have identified that sildenafil improves the flexibility of the heart’s ventricle walls by releasing an enzyme which in in turn causes the molecular protein in cells to soften and relax.

Sildenafil restrains the enzyme which assists the body’s blood flow inconsistently in different areas of the human body and although it increases blood flow to the penis by suppressing the phosphodiesterase enzyme, the new study showed that sildenafil causes the heart muscle protein, titin to relax.

Doctors have been aware that a reduced capacity of heart muscle to stretch is the cause of diastolic heart failure for many years. The condition is caused by a variety of factors, including blocked arteries, cardiomyopathy and high, unregulated blood pressure; however, it has not been possible to successfully treat the disease until now because of a lack of suitable drugs. This new study has been able to clarify how Viagra may be able to change and improve this situation to offer relief to thousands of people right across the world.

The recent research confirms that people suffering from diastolic heart failure have overly rigid heart ventricles and as a result the heart chambers aren’t supplied with adequate amounts of blood. This mismatch of pressure has the effect of causing blood to ‘hold’ into the air spaces of the patients lungs and subsequently causes extreme breathing hardships. Pulmonary edema which was caused as a result of a dysfunctional diastolic condition cannot be fully transmitted by a failing pump and symptoms may be incredibly sudden or insidious and spread over a long period of time.

The study was able to show how sildenafil inhibits one particular enzyme, which causes an increase in the formation of messenger matter; this substance in turn activates the protein which attaches groups of phosphate to other proteins. This process is referred to as ‘phosphorylation’ and is what causes the blood vessels to relax, which brings us full circle back to why Viagra was originally introduced to the market.

Researchers from both the Mayo Clinic in Minnesota and Ruhr Universitat in Germany were led by Dr Wolfgang Linke from the German university’s Physiology department and the findings were so positive that a patient trial is already being carried out in America.

Dr Linke told the journal ‘circulation’ that if the trial is able to confirm that Viagra has a positive effect of this particular type of heart disease, the molecular mechanism will already be on hand to explain why.